Insufficient availability of molten salt corrosion-resistant alloys severely limits the fruition of a variety of  promising molten salt technologies that could otherwise have significant societal impacts. To accelerate  alloy development for molten salt applications and develop fundamental understanding of corrosion in these  environments, here we present an integrated approach using a set of high-throughput alloy synthesis,  corrosion testing, and modeling coupled with automated characterization and machine learning. By using  this approach, a broad range of Cr-Fe-Mn-Ni alloys were evaluated for their corrosion resistances in molten  salt simultaneously demonstrating that corrosion-resistant alloy development can be accelerated by  thousands of times. Based on the obtained results, we unveiled a sacrificial mechanism in the corrosion of  Cr-Fe-Mn-Ni alloys in molten salts which can be applied to protect the less unstable elements in the alloy from being depleted, and provided new insights on the design of high-temperature molten salt corrosion resistant alloys.